Currently around 5,000 papers regarding LLLT called photobiomodulation have been published. From these papers, outstanding papers have been reported on the American national institute of health, national medical library (National Center for Biotechnology Information website – NCBI).
Click the link below to see the appropriate research at the NIH website. On the menu on the right of this website, you can read research papers that are similar to the mentioned above.
P.I. Quietmind Foundation, 1016 Greenwood Ave, Wyncote PA 19095, USA, 2017 Feb 28t
(REGEnLIFE, Montpellier, France, Amylgen, Montferrier-sur-Lez, France, 2018 Feb 2nd)
There is an evidence that Photobiomodultion (PBM) has positive effect on the brain. (Boston Massachusetts General HospitalWellman Center Dec 6th 2016)
Transcranial photobiomodulation is a potential innovative noninvasive therapeutic approach for improving brain bioenergetics, brain function in a wide range of neurological and psychiatric disorders, and memory enhancement in age-related cognitive decline and neurodegenerative diseases.
(Austrailia, Newsouthwales Sydney University Bosch Institute 2018 Jan 31st)
Near-infrared wavelengths (800-900 nm) and red (600 nm) light-emitting diodes (LED) are able to penetrate through the scalp and skull and have the potential to improve the subnormal cellular activity of compromised brain tissue (Brazil San Paulo Medical school neurosurgical department, 2018 April 24th)
(Boston Massachusetts, VA Boston medical system, 2016 Dec 1st
Brain damage, such as Traumatic Brain Injury (TBI) treatment including Low-Level Laser Therapy (LLLT) or PBM (Photobiomodulation)
There was significant improvement after 12 weeks of PBM. Increased function, better sleep, fewer angry outbursts, less anxiety, and wandering were reported post-PBM. (Canada Ontario Orangeville Medical Committee 2017 Aug 1st)
Parkinsonian (MPTP) insult and/or photobiomodulation (670 nm) had any impact on encephalopsin expression in this key area… (Department of Anatomy F13, University of Sydney, Sydney, 2006, Australia, 2018 Jan 29th)
University of Grenoble Alpes, CEA, LETI, CLINATEX, MINATEC Campus, 38000, 2017 Oct)
Suggest that the applications of LLLT are much broader than at first conceived (Briarcliiff High school, Briarcliff Manor, NY, USA, 2016 Dec 14th)
(Wellman Center for photomedicine, Massachusetts General Hospital, Boston, MA, 2017 Nov, 13th)
PBM treatment helps
There is also much research going on to PMB treat stroke, depression, dementia, and Parkinson's
These findings provide strong support for the promising therapeutic effect of PBM on neuronal repair following ischemic stroke. (Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA 2017 Oct 19th)
(McLean Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, 2017 August 1st)
Combined treatment strategies based on magnetic nanoparticles (MNPs) with near infrared ray (NIR) biophotonic possess tremendous potential (Medicine, Florida International University, Miami, Florida, 33199, USA, 2016 July 28th)
In the research, controlled group with traumatic brain injury (TBI) gave a significant improvement in neurological/cognitive function (Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA, 2016 March 15th)
After 1 week of PBM treatment, TBI patients showed 1 hour of increased sleep. (VA Boston Healthcare System, Boston, Massachusetts, 2015 September 1st)
(Department of psychology and institute for Neuroscience, University of Texas at Austin, Austin, TX, 78712, USA, 2017 May 2nd)
Application of red/NIR light improves mitochondrial function (especially in hypoxic/compromised cells) promoting increased adenosine triphosphate (ATP) important for cellular metabolism. Nitric oxide is released locally, increasing regional cerebral blood flow. Participants reported improved sleep, and fewer post-traumatic stress disorder (PTSD) symptoms, if present. (VA, Boston Healthcare System, Boston, Massachusetts, 2014 June 1st)
PBM shown to improve locomotor activity and to neuroprotect midbrain dopaminergic cells in rodent and monkey models of Parkinson's disease (Department of Anatomy F13, University of Sydney, Sydney, 2006, Austrailia, 2017 March 15th)
The use of PBM significantly reduced the presence of Aβ plaques and improved spatial memory and behavioral and motor skills in treated animals on day 21.
Although laser therapy on human tissue has been used since the late 1960s, it is only recently that several clinical studies have shown its value in raising neurometabolic energy levels that can improve cerebral hemodynamics and cognitive abilities in humans.
Result of NIr treatment showed that MPTP induced Astrogliosis have significantly decreased (Department of Anatomy, F13, University of Sydney, Sydney, 2006, Austrailia, 2016 July 5th)
(Department of Anatomy F13, University of Sydney, Sydney, 2006, Australia, 2016년 7월 5일)
Cardiovascular and cerebrovascular diseases are major risk factors in the development of cognitive impairment and Alzheimer's disease (AD). These cardio-cerebral disorders promote a variety of vascular risk factors which in the presence of advancing age are prone to markedly reduce cerebral perfusion and create a neuronal energy crisis (Departmnet of psychology, University of Texas at Austin, Austin, TX, 2016 June 20th)
The results showed that behavioral problems decreased regardless of the timing of root treatment (CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble Alpes, 38000, Grenoble, France, 2016)
Postoperative cognitive dysfunction (POCD) is a decline in memory following anaesthesia and surgery in elderly patients. Photobiomodulation (PBM) is an effective treatment for a number of conditions, including inflammation (University of Sydney, Sydney, NSW Austrailia, 2016 Jan 11th)
“Here we propose NIr therapy as a neuroprotective or disease-modifying treatment for Alzheimer's and Parkinson's patients (Department of Physiology, University of Sydney, Sydney, NSW Australia, 2016 Oct 19th)
Photobiomodulation effects of the low-energy laser and LED radiation is also considered as a potential tool for the rehabilitation of patients with various pathologies, yielding positive results in both PD and AD. (MedlinePlus Trusted Health Information for you, 2016 vol.96)
Deliver near-infrared light (NIr) to the midbrain of 6-hydroxydopamine (6-OHDA)-lesioned rats, a model of Parkinson's disease (CEA, Leti, and Clinatec Departments, University Grenoble Alpes, Minatec Campus, Grenoble, France; 2015 Nov 27th)
(Centre de Recherche du Centre Hospitalier de Québec, Axe Neuroscience et Département de Médecine Moléculaire de l'Université Laval, Québec, G1V4G2, Canada, 2015 Oct 20th)
Photobiomodulation (PBM) appears promising to treat the hallmarks of Parkinson's Disease (PD) in cellular or animal models (Federal Institute of Technology (EPFL), Institute of Chemical Sciences and Engineering (ISIC), 1015 Lausanne, Switzerland, 2015, March 19th)
Photobiomodulation (PBM) also known as low-level light therapy (LLLT) has been used successfully for the treatment of injury and disease of the nervous system. (LumiThera, Inc., Poulsbo, Washington, 98370, 2015 March 13th)
Our results, in two transgenic mouse models, suggest that NIr may have potential as an effective, minimally-invasive intervention for mitigating, and even reversing, progressive cerebral degenerations (University of Sydney NSW 2006, Austrailia, 2014 Jan 3rd)
Improving brain mitochondrial respiration is an important future direction in research and treatment of Alzheimer's disease (AD) and other conditions associated with cognitive impairment and neurodegeneration. (USA; Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA, 2014 April 15th)
(CEA-Leti, Grenoble, France; and, 2013 Oct 25th)
NIr treatment saves dopaminergic cells in the parkinsonian condition (Discipline of Physiology, University of Sydney, Australia; Bosch Institute, University of Sydney, Australia, 2013)
Stimulation of lateral brain using red NIr light leads to transforming biological function or uses a non-destructive method to induce neurological treatment effect.
(CEA, LETI, CLINATEC, Grenoble 38054, France, 2013 March 27th)
(Cardiothoracic Surgery Department, Easton Hospital, Easton, Pennsylvania, USA, 2012 Sept 11th)
(Department of Neurology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA, 2012 July 13th)
(Department of Health Sciences, College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America, 2012 Jan 24th)
(Discipline of Anatomy & Histology F13, University of Sydney, Australia, 2012 Jan 28th)
Department of Psychology, Pharmacology and Toxicology, University of Texas at Austin, Austin, TX, 2011 Oct 14th)
It is shown that LPLI decreases Aβ induced apoptosis
Group with acute traumatic brain injury (TBI) or acute stroke gave a significant improvement in neurological/cognitive function (Boston Healthcare System , Boston, Massachusetts, 2010 Jan 23rd)
“ Data collected to date, PBM appears to be a promising treatment for depression” (Massachusetts General Hospital 02114, 2016 March 4th)
(Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, Boston, MA 02114, USA. 2010 Dec 2nd)
(Wellman Center for Photomedicine , Massachusetts hospital , Boston , MA 02114 , USA, 2016, JAN)
(VA Boston Healthcare System (12-A) , Boston, Massachusetts, 2016 Dec 1st)
Significant improvement was reported after applying LLLT to human moel with storke and a mouse model with acute TBI (VA Boston Healthcare System , Boston, Massachusetts, 2010 Dec 23rd)
(Department of Psychology, Brigham Young University Provo, UT, USA ; Neuroscience Center, Brigham Young University Provo, UT, USA, 2013년 8월 6일)
(Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA, 2004 Nov 22nd)
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